Kloratsepaatti Käyttö | Lähteet | Navigointivalikko23887-31-2BA052809DB00628eMoleculesPubChemComparative single-dose kinetics of oxazolam, prazepam, and clorazepate: three precursors of desmethyldiazepamTranxene prescribing information in the Netherlands (Dutch language)10.1016/0014-2999(78)90085-7Systematic review of the benzodiazepines. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Committee on the Review of Medicines10.1136/bmj.280.6218.910

BentsodiatsepiinitUnilääkkeet


bentsodiatsepiinijohdannainennordiatsepaaminaihiolääkediatsepaamioksatsepaamiloratsepaaminitratsepaamibromatsepaamifluratsepaamibarbeksaklonifenobarbitaalimetarbitaalimetyylifenobarbitaalipentobarbitaaliprimidonifelbamaattidiatsepaamiklobatsaamiklonatsepaamikloratsepaattiloratsepaamimidatsolaaminimetatsepaaminitratsepaamitematsepaamibromidikaliumbromidinatriumbromidiimepitoiiniparaldehydistiripentolivalproaattivalpromidivalproaatti pivoksiilivigabatriiniprogabiditiagabiinietotoiinifenytoiinifosfenytoiinimefenytoiinieslikarbatsepiiniasetaattikarbamatsepiiniokskarbatsepiinilakosamidilamotrigiinirufinamiditopiramaattitsonisamidietadioniparametadionitrimetadionietosuksimidifensuksimidimesuksimidigabapentiinipregabaliini




































Kloratsepaatti

Kloratsepaatti


Systemaattinen (IUPAC) nimi
7-kloori-2-okso-5-fenyyli-1,3-dihydro-1,4-bentsodiatsepiini-3-karboksyylihappo

Tunnisteet

CAS-numero

23887-31-2

ATC-koodi

N05BA05

PubChem

2809

DrugBank

DB00628

Kemialliset tiedot

Kaava

C16H11N2ClO3 

Moolimassa
314,72 g/mol

SMILES
Etsi tietokannasta: eMolecules, PubChem

Farmakokineettiset tiedot

Hyötyosuus
91%

Proteiinisitoutuminen
97-98%

Metabolia

Hepaattinen

Puoliintumisaika
40-50 tuntia

Ekskreetio

Renaalinen

Terapeuttiset näkökohdat

Raskauskategoria

?



Reseptiluokitus


Antotapa
Oraalinen


Tranxene 10mg -tabletteja.


Kloratsepaatti on bentsodiatsepiinijohdannainen rauhoittava lääke. Sillä on ahdistusta poistava, lihaksia relaksoiva, sedatiivinen ja unettava vaikutus.



Käyttö |


Kloratsepaatti on nordiatsepaamin aihiolääke.[1]


Kloratsepaattia voidaan käyttää sekä rauhoittavana lääkkeenä, että alkoholin vieroitusoireisiin ja epilepsiaan.


Kloratsepaattia myydään tuotenimillä Tranxene ja Novo-Klopate, ja sen tavallinen aloitusannos on 15–60 mg päivässä, jaettuna neljään annokseen päivässä.



Annostus |


Tavallinen annostus on 90–120 mg päivässä, alkoholin vieroitusoireita hoidettaessa. Yhdysvalloissa ja Kanadassa kloratsepaattia saa 3,75 mg, 7,5 mg ja 15 mg tabletteina tai kapseleina. Euroopassa tabletit ovat 5 mg, 10 mg, 20 mg tai 50 mg.[2]


Kloratsepaatti on "klassinen bentsodiatsepiini". Muita klassisia bentsodiatsepiineja ovat diatsepaami, oksatsepaami, loratsepaami, nitratsepaami, bromatsepaami ja fluratsepaami.[3] Kloratsepaatti on pitkävaikutteinen bentsodiatsepiini, sen puoliintumisaika veriplasmassa on 48 tuntia.[4]


Kloratsepaatti vapautuu hitaasti elimistöön: tämän vuoksi sen pitoisuus veriplasmassa on tasainen, joka voi olla hyödyllinen ominaisuus epileptikoille, tai henkilöille jotka saattavat unohtaa ottaa lääkettä ja saavat voimakkaita kramppeja lääkkeen pitoisuuden laskiessa veressä.[5]



Lähteet |



  1. ↑ Ochs HR, Greenblatt DJ, Verburg-Ochs B, Locniskar A (October 1984). "Comparative single-dose kinetics of oxazolam, prazepam, and clorazepate: three precursors of desmethyldiazepam". J Clin Pharmacol 24 (10): 446–51. PMID 6150943. 



  2. ↑ Tranxene prescribing information in the Netherlands (Dutch language); accessed 2007-03-08.


  3. ↑ Braestrup C; Squires RF. (1 April 1978). "Pharmacological characterization of benzodiazepine receptors in the brain". Eur J Pharmacol 48 (3): 263–70. doi:10.1016/0014-2999(78)90085-7. PMID 639854. 



  4. ↑ The Committee on the Review of Medicines (CRM) (March 29, 1980). "Systematic review of the benzodiazepines. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Committee on the Review of Medicines". Br Med J. 280 (6218): 910–2. doi:10.1136/bmj.280.6218.910. PMID 7388368. 



  5. ↑ http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0404.2008.01004.x/pdf



Käännös suomeksi
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Antikonvulsantit










GABAergiset


GABAAR PAM


Barbituraatit: barbeksakloni • fenobarbitaali • metarbitaali • metyylifenobarbitaali • pentobarbitaali •primidoni • Karbamaatit: felbamaatti • Bentsodiatsepiinit: diatsepaami • klobatsaami  • klonatsepaami • kloratsepaatti • loratsepaami • midatsolaami • nimetatsepaami • nitratsepaami • tematsepaami • Muut: bromidi (kaliumbromidi, natriumbromidi) • imepitoiini • paraldehydi • stiripentoli


GABA-T -inhibiittorit

Rasvahapot (ja liittyvät): valproaatti • valpromidi • valproaatti pivoksiili • vigabatriini


Muut

GABAR-reseptorinaktivoijat: progabidi • GAT-1 -inhibiittorit: tiagabiini







Kanavamodulaattorit


Natrium-salpaajat


Hydantoiinit: etotoiini • fenytoiini • fosfenytoiini • mefenytoiini • Karboksamidit: eslikarbatsepiiniasetaatti • karbamatsepiini • okskarbatsepiini • Muut: lakosamidi • lamotrigiini • rufinamidi • topiramaatti • tsonisamidi



Kalsium-salpaajaat

Oksatsolidiinidionit: etadioni • parametadioni • trimetadioni • Suksinimidit: etosuksimidi •fensuksimidi • mesuksimidi • Gabapentinoidit: gabapentiini • pregabaliini









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