B-solu Muodostuminen | Toimintaperiaate | Lähteet | Navigointivalikkolaajentamalla

VerisolutImmunologia


immuunijärjestelmänsoluihinlymfosyytteihinverenluuytimessäkantasoluistaT-imusolutsolukalvossavasta-aineita







Plasmasolu.


B-solut kuuluvat immuunijärjestelmän soluihin eli lymfosyytteihin. Ne huolehtivat osaltaan elimistön spesifisen puolustusjärjestelmän humoraalisesta eli vasta-ainevälitteisestä immuniteetista. B-soluista käytetään myös nimityksiä B-imusolu ja B-lymfosyytti, ja niiden osuus on noin 20 % veren kaikista imusoluista.[1]



Muodostuminen |


B-imusolut muodostuvat luuytimessä olevista kantasoluista ja jäävät myös kypsymään luuytimeen toisin kuin T-imusolut. Kypsymisen jälkeen B-solut kulkevat veren mukana sekundaarisiin imukudoselimiin, joihin ne pysähtyvät ja alkavat jakautua. Muodostuminen ja kypsyminen jatkuvat koko elämän ajan.[1]


Kun B-imusolut aktivoituvat, suurin osa niistä erilaistuu vasta-aineita tuottaviksi plasmasoluiksi ja osasta kehittyy B-muistisoluja.[1]



Toimintaperiaate |


Jokaisen B-imusolun solukalvossa on tuhansia samanlaisia antigeenireseptorimolekyylejä, jotka sitoutuvat kukin omaan antigeenityyppiinsä. Sitoutumisen jälkeen B-solu erilaistuu plasmasoluksi, joka alkaa tuottaa solun pinnan antigeenireseptorien kaltaisia vasta-aineita.[1] Vasta-aineet kiertävät imunesteen ja veren mukana ja sitovat kohtaamiaan antigeenejä aiheuttaen niiden tuhoutumisen.[2]



Lähteet |



  1. ↑ abcd Haug, Sand, Sjaastad: Ihmisen fysiologia, s. 327-328. Porvoo: WSOY, 1999. ISBN 951-0-19882-x.


  2. ↑ Haug, Sand, Sjaastad: Ihmisen fysiologia, s. 333-334. Porvoo: WSOY, 1999. ISBN 951-0-19882-x.



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