Enoksimoni Sisällysluettelo Ominaisuudet ja käyttökohteet | Haittavaikutukset | Synteesi | Lähteet | Navigointivalikko77671-31-9CE0353708DB04880eMoleculesPubChemEnoximoneKirja Googlen teoshaussaKirja Googlen teoshaussaKirja Googlen teoshaussaKirja Googlen teoshaussa

Sydänlääkkeet


imidatsolonijohdannaisiinorgaaninen yhdistekongestiivisen sydämen vajaatoiminnanfosfodiesteraasi 3inhibiittorisyklisen adenosiinimonofosfaatintrombosytopeniahydroksiasetoniureap-klooribentsoehappo






































Enoksimoni

Enoksimoni


Systemaattinen (IUPAC) nimi
4-metyyli-5-(4-metyylisulfanyylibentsoyyli)-1,3-dihydroimidatsol-2-oni

Tunnisteet

CAS-numero

77671-31-9

ATC-koodi

C01CE03

PubChem

53708

DrugBank

DB04880

Kemialliset tiedot

Kaava

C12H12N2O2S 

Moolimassa
248,306

SMILES
Etsi tietokannasta: eMolecules, PubChem

Fysikaaliset tiedot

Sulamispiste
255–258 °C (491–496 °F) (hajoaa)[1]

Farmakokineettiset tiedot

Hyötyosuus
50 % (oraalinen)[2]

Proteiinisitoutuminen
85 %[2]

Metabolia

Hepaattinen

Puoliintumisaika
4-10 h[2]

Ekskreetio
?

Terapeuttiset näkökohdat

Raskauskategoria

?



Reseptiluokitus


Antotapa
Oraalinen, intravenoosi

Enoksimoni (C12H12SN2O2) on imidatsolonijohdannaisiin kuuluva orgaaninen yhdiste. Yhdistettä voidaan käyttää lääketieteessä kongestiivisen sydämen vajaatoiminnan hoitamiseen.




Sisällysluettelo





  • 1 Ominaisuudet ja käyttökohteet


  • 2 Haittavaikutukset


  • 3 Synteesi


  • 4 Lähteet




Ominaisuudet ja käyttökohteet |


Enoksimoni on fosfodiesteraasi 3 -entsyymin inhibiittori. Yhdiste estää syklisen adenosiinimonofosfaatin hajoamista. Tämän seurauksena kalsiumionien virtaus sydänsoluissa sydämen aktiopotentiaalin aikana kasvaa ja sydämen verisuonet laajenevat. Enoksimonin on myös havaittu lisäävän sydämen lyöntitiheyttä. Lääkeainetta annostellaan joko suun kautta tai suonensisäisesti. Enoksimonin on havaittu olevan tehokkain erityisesti lievissä tapauksissa, mutta vaikeissa kongestiivisissa sydämen vajaatoiminnoissa se voi jopa lisätä kuolleisuutta.[2][3][4][5][6]



Haittavaikutukset |


Tyypillisimpiä enoksimonin haittavaikutuksia ovat vatsaoireet kuten vatsakipu, huonovointisuus ja oksentelu, anoreksiapääkipu, väsymys, lisääntynyt ruokahalu, trombosytopenia, allergiset iho-oireet, sydämen toimintahäiriöt ja levottomuus.[3][7]



Synteesi |


Enoksimonin synteesin lähtöaineita ovat hydroksiasetoni, urea, natriummetyylimerkaptidi ja p-klooribentsoehappo.[8]



Lähteet |



  1. ↑ Susan Budavari (päätoim.): Merck Index, s. 607-608. 12th Edition. Merck & Co., 1996. ISBN 0911910-12-3. (englanniksi)


  2. ↑ abcd Enoximone DrugBank. Viitattu 30.1.2016. (englanniksi)


  3. ↑ ab Hans P. Albrecht & Karl-Heinz Geiss: Cardiac Glycosides and Synthetic Cardiotonic Drugs, Ullmann's Encyclopedia of Industrial Chemistry, John Wiley & Sons, New York, 2000. Viitattu 30.1.2016


  4. ↑ Patrick M. McCarthy,James B. Young: Heart Failure, s. 51. John Wiley & Sons, 2008. ISBN 978-1-4051-8134-1. Kirja Googlen teoshaussa (viitattu 30.1.2016). (englanniksi)


  5. ↑ T. E. Peck,S. A. Hill: Pharmacology for Anaesthesia and Intensive Care, s. 204. Cambridge University Press, 2014. ISBN 99781107657267. Kirja Googlen teoshaussa (viitattu 30.1.2016). (englanniksi)


  6. ↑ Lionel H. Opie,Bernard J. Gersh: Drugs for the Heart, s. 183. Elsevier, 2012. ISBN 9781455733224. Kirja Googlen teoshaussa (viitattu 30.1.2016). (englanniksi)


  7. ↑ Jeffrey K. Aronson: Meyler's Side Effects of Cardiovascular Drugs, s. 168. Elsevier, 2009. ISBN 978-0-444-53268-8. Kirja Googlen teoshaussa (viitattu 30.1.2016). (englanniksi)


  8. ↑ Robert D. Ashford: Ashford's Dictionary of Industrial Chemicals, s. 469. 2nd Edition. Wavelength Publications, 2001. ISBN 0-9522674-2-X. (englanniksi)








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