Pyratsolaami Lähteet | Navigointivalikko39243-02-212562545eMoleculesPubChem10.1007/s11419-013-0187-4Characterization of the designer benzodiazepines pyrazolam and flubromazepam and study on their detectability in human serum and urine sampleslaajentamalla

AnksiolyytitBentsodiatsepiinit


bentsodiatsepiinijohdannainenHoffmann-La Rochellamuuntohuumeenaalpratsolaaminbromatsepaaminmetaboloiduvirtsaananksiolyyttinä
































Pyratsolaami

Pyratsolaami


Systemaattinen (IUPAC) nimi
8-bromi-1-metyyli-6-(pyridin-2-yyli)-4H'"-[1,2,4]triatsolo[4,3-''][1,4]bentsodiatsepiini

Tunnisteet

CAS-numero

39243-02-2

ATC-koodi
?

PubChem

12562545

Kemialliset tiedot

Kaava

C16H12N5Br 

Moolimassa
354.204 g/mol

SMILES
Etsi tietokannasta: eMolecules, PubChem

Farmakokineettiset tiedot

Hyötyosuus
?

Metabolia
?

Puoliintumisaika
17 h

Ekskreetio
?

Terapeuttiset näkökohdat

Raskauskategoria

?



Reseptiluokitus


Antotapa
oraalinen, sublinguaalinen, rektaalinen

Pyratsolaami on bentsodiatsepiinijohdannainen jonka kehitti Leo Sternbachin johtama tiimi Hoffmann-La Rochella 1970-luvulla.[1] Sittemmin aine "löydettiin uudestaan", ja sitä on myyty muuntohuumeena vuodesta 2012 asti.[2]


Pyratsolaamilla on rakenteellisia samankaltaisuuksia alpratsolaamin[3] ja bromatsepaamin kanssa.


Muista bentsodiatsepiineista poiketen pyratsolaami ei metaboloidu, vaan se erittyy sellaisenaan virtsaan.[2][4]


Pyratsolaami toimii lähes pelkästään anksiolyyttinä, eikä sillä ole juuri muita vaikutuksia.lähde?



Lähteet |



  1. ↑ Cite patent | country=US |number= 3954728 | title =Preparation of triazolo benzodiazepines and novel compounds


  2. ↑ ab "Characterization of the designer benzodiazepine pyrazolam and its detectability in human serum and urine" (2013). Forensic Toxicology 31 (2): 263. doi:10.1007/s11419-013-0187-4. 



  3. ↑ "6-Phenyl-4H-s-triazolo[4,3-a][l,4]benzodiazepines Which Have Central Nervous System Depressant Activity" (1971). J. Med. Chem 14 (11): 1078–1081. PMID 5165540. 



  4. ↑ Characterization of the designer benzodiazepines pyrazolam and flubromazepam and study on their detectability in human serum and urine samples, B. Moosmann, M. Hutter, L. M. Huppertz and V. Auwärter



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